It works well for me.
I do have the kids with a "partner" for reading workshop, meeting area, etc. I partner them up and they sit side by side when we are in the floor. They can turn and talk, go to their reading spot, etc.
When we are at our desks it is usually just to work on math or writing workshop, etc. But the way the desks are arranged they still have someone beside them. I actually have one fewer desk on the "end" now because we added another class due to large enrollment. Each group of desks are for six kids.