My mom cannot take NyQuil--keeps her up all night, ditto Benadryl. I'm the opposite--Benadryl, NyQuil, Sudafed, and similar meds knock me out COLD. DD couldn't take the liquid Benadryl unless it was the "dye-free" version. It does the same thing for her that it does for her Grammie!
Ima--hydrocodone is funky! After my surgery I'd take it so I could sleep but all it did was give me "hot flashes"--not wild, though!